Research Interests - Epigenetics and Cancer:
Chromatin is decorated with
many different types of modification on histones and on DNA. These can potentially
effect any biological process. Our lab is involved in identifying and characterising
modifications of histones, primarily concentrating on their role in transcription. Our
interest is fueled by the fact that many of these modification pathways are deregulated in cancer. We are keen to
understand how miss-regulation generates uncontrolled cell growth and in finding small molecule inhibitors that can target the damaged pathway in cancer cells.
For more information see the About
the Lab section.
• Selected Recent Publications:
B, Robson SC, Kouzarides T. (2012)
Human RNA Methyltransferase BCDIN3D Regulates MicroRNA Processing.
Cell. 151(2), 278-288.
Dawson MA, Kouzarides T. (2012)
Cancer epigenetics: from mechanism to therapy.
Cell. 150(1), 12-27.
MA, Prinjha RK, Dittman A, Giotopoulos G, Bantscheff M, Chan WI,
Robson SC, Chung CW, Hopf C, Savitski MM, Huthmacher C, Gudgin
E, Lugo D, Beinke S, Chapman TD, Roberts EJ, Soden PE, Auger KR,
Mirguet O, Doehner K, Delwel R, Burnett AK, Jeffrey P, Drewes G,
Lee K, Huntly BJ, Kouzarides T. (2011)
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.
Nature. 478(7370), 529-533.
Bartke T, Vermeulen M, Xhemalce B, Robson SC, Mann M, Kouzarides T. (2010)
Nucleosome-interacting proteins regulated by DNA and histone methylation.
Cell. 143(3), 470-484.
See Also: Entire