Recent publications from the Livesey Lab, with links to:

·A· Abstract,

·P· Pubmed.

First/Last Author Papers

• Neng-Wei Hu, Grant T. Corbett, Steven Moore, Igor Klyubin, Tiernan T. O’Malley, Dominic M. Walsh, Frederick J. Livesey, Michael J. Rowan (2018)  Extracellular Forms of Aβ and Tau from iPSC Models of Alzheimer’s Disease Disrupt Synaptic Plasticity  Cell Reports Vol 23, Issue 7, p1932–1938   ·A·  ·P·

• Lewis D.Evans, Thomas Wassmer, Graham Fraser, James Smith, Michael Perkinton, Andrew Billinton, Frederick J.Livesey, (2018)  Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways  Cell Reports Vol 22, Issue 13, p3612-3624   ·A·  ·P·

• Philip W. Brownjohn, James Smith, Ravi Solanki, Ebba Lohmann, Henry Houlden, John Hardy, Sabine Dietmann, Frederick J. Livesey, (2018)  Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia  Stem Cell Reports Vol 10, Issue 4, p1294-1307   ·A·  ·P·

• Philip W. Brownjohn, James Smith, Erik Portelius, Lutgarde Serneels, Hlin Kvartsberg, Bart De Strooper, Kaj Blennow, Henrik Zetterberg, Frederick J. Livesey, (2017)  Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer’s Disease  Stem Cell Reports Vol. 8 j 1–13   ·A·  ·P·

• Tomoki Otani, Maria C. Marchetto, Fred H. Gage, Benjamin D. Simons, Frederick J. Livesey, (2016)  2D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain Size  Cell Stem Cell   ·A·  ·P·

• Peter Kirwan, Benita Turner-Bridger, Manuel Peter, Ayiba Momoh, Devika Arambepola, Hugh P. C. Robinson and Frederick J. Livesey, (2015)  Development and function of human cerebral cortex neural networks from pluripotent stem cells in vitro  Development 142, 3178-3187   ·A·  ·P·

• Steven Moore, Lewis D.B. Evans, Therese Andersson, Erik Portelius, James Smith, Tatyana B. Dias, Nathalie Saurat, Amelia McGlade, Peter Kirwan, Kaj Blennow, John Hardy, Henrik Zetterberg, Frederick J. Livesey (2015)  APP Metabolism Regulates Tau Proteostasis in Human Cerebral Cortex Neurons  Cell Reports V11 i5, p689–696   ·A·  ·P·

• Nathalie Saurat, Therese Andersson, Navneet A Vasistha, Zoltán Molnár and Frederick J Livesey (2013)  Dicer is required for neural stem cell multipotency and lineage progression during cerebral cortex development  Neural Development 8(1):14   ·A·  ·P·

• Jessica M. Alsiö, Basile Tarchini, Michel Cayouette and Frederick J. Livesey (2013)  Ikaros promotes early-born neuronal fates in the cerebral cortex  PNAS 1215707110   ·A·  ·P·

• Yichen Shi, Peter Kirwan, and Frederick J. Livesey (2012)  Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks  Nature Protocols 7, 1836–1846   ·A·  ·P·

• Yichen Shi, Peter Kirwan, James Smith, Glenn MacLean, Stuart H. Orkin and Frederick J. Livesey (2012)  A Human Stem Cell Model of Early Alzheimer’s Disease Pathology in Down Syndrome  Science Translational Medicine (aop)   ·A·  ·P·

• Yichen Shi, Peter Kirwan, James Smith, Hugh P C Robinson, Frederick J Livesey (2012)  Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses  Nature Neuroscience (aop)   ·A·  ·P·

• Therese Andersson, Sabhi Rahman, Stephen N. Sansom, Jessica M. Alsiö, Masahiro Kaneda, James Smith, Donal O'Carroll, Alexander Tarakhovsky, Frederick J. Livesey (2011)  Reversible Block of Mouse Neural Stem Cell Differentiation in the Absence of Dicer and MicroRNAs  PLoS ONE 5(10) e13453   ·A·  ·P·

• João D. Pereira, Stephen N. Sansom, James Smith, Marc-Werner Dobenecker, Alexander Tarakhovsky, and Frederick J. Livesey (2010)  Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex  PNAS 1002530107   ·A·  ·P·

• Tatiana Subkhankulova, Kojiro Yano, Hugh P. C. Robinson and Frederick J. Livesey (2010)  Grouping and classifying electrophysiologically-defined classes of neocortical neurons by single cell, whole-genome expression profiling.  Front Mol Neurosci. 2010 Apr 13;3:10.   ·A·  ·P·

• Stephen N. Sansom, Dean S. Griffiths, Andrea Faedo, Dirk-Jan Kleinjan, Youlin Ruan, James Smith, Veronica van Heyningen, John L. Rubenstein, Frederick J. Livesey (2009)  The Level of the Transcription Factor Pax6 Is Essential for Controlling the Balance between Neural Stem Cell Self-Renewal and Neurogenesis.  PLOS Genetics 5(6): e1000511.   ·A·  ·P·

• Tatiana Subkhankulova, Michael J Gilchrist and Frederick J Livesey (2008)  Modelling and measuring single cell RNA expression levels find considerable transcriptional differences among phenotypically identical cells.  BMC Genomics 2008, 9:268.   ·A·  ·P·

• Cobb, B. S., Hertweck, A., Smith, J., O'Connor, E., Graf, D., Cook, T., Smale, S. T., Sakaguchi, S., Livesey, F. J., Fisher, A. G., and Merkenschlager, M. (2006)  A role for Dicer in immune regulation.  J. Exp. Med. 203: 2519-2527.   ·A·  ·P·

• Subkhankulova, T. and Livesey, F. J. (2006)  Comparative evaluation of linear and exponential amplification techniques for expression profiling at the single cell level.  Genome Biology,7: R18.   ·A·  ·P·

• Sansom, S.N., Hebert, J.M., Thammongkol, U., Smith, J., Nisbet, G., Surani, M.A., McConnell, S.K. and Livesey, F.J. (2005)  Genomic characterisation of a Fgf-regulated gradient-based neocortical protomap.  Development 132: 3947-61.   ·A·  ·P·

• Livesey, F.J. Young, T.L. and Cepko, C.L. (2004)  An analysis of the gene expression program of mammalian neural progenitor cells.  PNAS 101:1374-1379.   ·A·  ·P·

Reviews and book chapters

• Nathalie G. Saurat, Frederick J. Livesey , Steven Moore (2016)  Cortical Differentiation of Human Pluripotent Cells for In Vitro Modeling of Alzheimer’s Disease.  Systems Biology of Alzheimer's Disease Vol 1303 of Methods in Molecular Biology pp 267-278   ·A·  ·P·

• Livesey, F.J. (2012)  Stem cell models of Alzheimer's disease and related neurological disorders.  Alzheimers Res Ther. 4(5):44   ·A·  ·P·

• Livesey, F.J. (2012)  A potential link between obesity and neural stem cell dysfunction.  Nat Cell Biol.14(10):987-9..   ·A·  ·P·

• Brand AH, Livesey FJ (2011)  Neural stem cell biology in vertebrates and invertebrates: more alike than different?  Neuron.70(4):719-29   ·A·  ·P·

• Sansom, S.N. and Livesey, F.J. Neural cell fate determination. In:  Principles of Developmental Genetics, Ed. Sally Moody, Elsevier, 2007   ·A·

• Brand, A. H., and Livesey, F. J. (2005)  Cell differentiation.  Curr Opin Cell Biol 17: 637-638.   ·A·

• Livesey, F.J. (2003)  Strategies for microarray analysis of limiting amounts of RNA.  Briefings in Functional Genomics and Proteomics, 12:1-5.   ·A·  ·P·

• Sansom, S., Rahman, S., Thammongkol, U. and Livesey, F.J.  Cell fate determination in neural stem cells. In:  Neural Stem Cells: Development and Transplantation, Ed. Jane Bottenstein, Kluwer Academic, 2003.

• Livesey, F.J. (2002)  Have microarrays failed to deliver for developmental biology?  Genome Biology, 3: 2009.

• Blackshaw, S. and Livesey, R. (2002)  Applying genomics technologies to neural development.  Current Opinion in Neurobiology, 12: 110-114.

Collaborative publications

• Vasja Urbančič, Richard Butler, Benjamin Richier, Manuel Peter, Julia Mason, Frederick J. Livesey, Christine E. Holt, Jennifer L. Gallop (2017).  Filopodyan: An open-source pipeline for the analysis of filopodia.  The Journal of Cell Biology   ·A·  ·P·

• Madeline A Lancaster, Nina S Corsini, Simone Wolfinger, E Hilary Gustafson, Alex W Phillips, Thomas R Burkard, Tomoki Otani, Frederick J Livesey & Juergen A Knoblich (2017).  Guided self-organization and cortical plate formation in human brain organoids  Nature Biotechnology   ·A·  ·P·

• Michael Willem, Sabina Tahirovic, Marc Aurel Busche, Saak V. Ovsepian, Magda Chafai, Scherazad Kootar, Daniel Hornburg, Lewis D. B. Evans, Steven Moore, Anna Daria, Heike Hampel, Veronika Müller, Camilla Giudici, Brigitte Nuscher, Andrea Wenninger-Weinzierl, Elisabeth Kremmer, Michael T. Heneka, Dietmar R. Thal, Vilmantas Giedraitis, Lars Lannfelt, Ulrike Müller, Frederick J. Livesey, Felix Meissner, Jochen Herms, Arthur Konnerth, Hélène Marie & Christian Haass (2015)  η-Secretase processing of APP inhibits neuronal activity in the hippocampus.  Nature doi:10.1038/nature14864   ·A·  ·P·

• Teresa Sposito, Elisavet Preza, Colin J. Mahoney, Núria Setó-Salvia, Natalie S. Ryan, Huw R. Morris, Charles Arber, Michael J. Devine, Henry Houlden, Thomas T. Warner, Trevor J. Bushell, Michele Zagnoni, Tilo Kunath, Frederick J. Livesey, Nick C. Fox, Martin N. Rossor, John Hardy, and Selina Wray (2015)  Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT  Hum. Mol. Genet. doi:10.1093/hmg/ddv246   ·A·  ·P·

• Fahad R. Ali, Kevin Cheng, Peter Kirwan, Su Metcalfe, Frederick J. Livesey, Roger A. Barker, and Anna Philpott (2014)  The phosphorylation status of Ascl1 is a key determinant of neuronal differentiation and maturation in vivo and in vitro.  Development 2014 141:2216-2224   ·A·  ·P·

• Bob Olsson, Laurence Legros, François Guilhot, Kia Strömberg, James Smith, Frederick J. Livesey, David H. Wilson, Henrik Zetterberg, Kaj Blennow (2013)  Imatinib treatment and Aβ42 in humans.  Alzheimer's and Dementia 2013 Dec 10  ·A·  ·P·

• Tuoc TC, Boretius S, Sansom SN, Pitulescu ME, Frahm J, Livesey FJ, Stoykova A (2013)  Chromatin regulation by BAF170 controls cerebral cortical size and thickness.  Dev Cell.25(3):256-69  ·P·

• Mi D, Carr CB, Georgala PA, Huang YT, Manuel MN, Jeanes E, Niisato E, Sansom SN, Livesey FJ, Theil T, Hasenpusch-Theil K, Simpson TI, Mason JO, Price DJ. (2013)  Pax6 exerts regional control of cortical progenitor proliferation via direct repression of Cdk6 and hypophosphorylation of pRb.  Neuron.78(2):269-84  ·P·

• Yano, K., Subkhankulova, T., Livesey, F.J., Robinson, H.P. (2006)  Electrophysiological and gene expression profiling of neuronal cell types in mammalian neocortex.  J. Physiol. 575:361-375.

• Pance, A., Livesey, F. J., and Jackson, A. P. (2006)  A role for the transcriptional repressor REST in maintaining the phenotype of neurosecretory-deficient PC12 cells.  J. Neurochem., 99: 1435-1444.

• Perry, P., Sauer, S., Billon, N., Richardson, W.D., Spivakov, M., Warnes, G., Livesey, F.J., Merkenschlager, M., Fisher, A.G., and Azuara, V. (2004) ; A Dynamic Switch in the Replication Timing of Key Regulator Genes in Embryonic Stem Cells upon Neural Induction.  Cell Cycle, 3: 1645-1650.

• Robinson, M., Parsons Perez, M.C., Tébar, L., Palmer, J., Patel, A., Marks, D.,Sheasby, A., De Felipe, C., Coffin, R., Livesey, F.J. and Hunt, S.P. (2004)  FLRT3 is Expressed in Sensory Neurons After Peripheral Nerve Injury and Regulates Neurite Outgrowth.  Mol. Cell. Neurosci, 27: 202-214.

• Kawasaki, H., Crowley, J.C., Livesey, F.J. and Katz, L.C. (2004)  Molecular organization of the ferret visual thalamus.  J. Neurosci., 24: 9962-9970.

• Dyer, M.A., Livesey, F.J., Cepko, C.L. and Oliver, G. (2003)  Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina.  Nature Genetics, 34: 53-58.