Research Publications
Reviews

Research Publications

  • Klapholz B., Herbert S.L., Wellmann J., Johnson R., Parsons M., Brown N.H. (2015) Alternative mechanisms for talin to mediate integrin function. Curr. Biol. 25(7), 847-857 PubMed

  • Huelsmann S., Ylänne J., Brown N.H. (2013) Filopodia-like Actin Cables Position Nuclei in Association with Perinuclear Actin in Drosophila Nurse Cells. Dev. Cell 26(6), 604-615 PubMed

  • Bulgakova N.A., Grigoriev I., Yap A.S., Akhmanova A., Brown N.H. (2013) Dynamic microtubules produce an asymmetric E-cadherin-Bazooka complex to maintain segment boundaries. J. Cell Biol. 201(6), 887-901 PubMed

  • Ratheesh, A., Gomez, G.A., Priya, R., Verma, S., Kovacs, E.M., Jiang, K., Brown, N.H., Akhmanova, A., Stehbens, S.J., Yap, A.S. (2012) Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens. Nat. Cell Biol. 14, 818-828 PubMed

  • Zervas, C.G., Psarra, E., Williams, V., Solomon, E., Vakaloglou, K.M., Brown, N.H. (2011) A central multifunctional role of integrin-linked kinase at muscle attachment sites. J. Cell Sci. 124, 1316-27. PubMed

  • Sabino, D., Brown, N.H., Basto, R. (2011) Drosophila Ajuba is not an Aurora-A activator but is required to maintain Aurora-A at the centrosome. J. Cell Sci. 124, 1156-66. PubMed

  • Bataille, L., Delon, I., Da Ponte, J.P., Brown, N.H., and Jagla, K. (2010) Downstream of Identity Genes: Muscle-Type-Specific Regulation of the Fusion Process. Dev. Cell 19, 317-328. PubMed

  • Tweedie, S., Ashburner, M., Falls, K., Leyland, P., McQuilton, P., Marygold, S., Millburn, G., Osumi-Sutherland, D., Schroeder, A., Seal, R., Zhang, H. and The FlyBase Consortium. (2009) FlyBase: enhancing Drosophila Gene Ontology annotations. Nucleic Acids Res. 37(Database issue):D555-D559. PubMed

  • Loevenich, S.N., Brunner, E., King, N.L., Deutsch, E.W., Stein, S.E., FlyBase Consortium, Aebersold, R., Hafen. E. (2009) The Drosophila melanogaster PeptideAtlas facilitates the use of peptide data for improved fly proteomics and genome annotation. BMC Bioinformatics. 10:59. PubMed

  • Delon, I. and Brown, N.H. (2009) The integrin adhesion complex changes its composition and function during morphogenesis of an epithelium. J. Cell Sci. 122, 4363-4374. PubMed

  • Urbano, J.M., Torgler, C. N., Molnar, C., Tepass, U., López-Varea, A., Brown, N.H., de Celis, J.F. and Martín-Bermudo,  M.D. (2009) Drosophila Laminins act as key regulators of basement membrane assembly and morphogenesis. Development 136, 4165-4176. PubMed

  • Narasimha, M., Uv, A., Krejci, A., Brown N.H., Bray S.J. (2008) Grainy head promotes expression of septate junction proteins and influences epithelial morphogenesis. J. Cell Sci. 121, 747-752. PubMed

  • Tanentzapf, G., Devenport, D., Godt, D., and Brown, N.H. (2007) Integrin-dependent anchoring of a stem-cell niche. Nature Cell Biol. 9, 1413-1418. PubMed

  • Devenport, D., Bunch, T.A., Bloor, J.W., Brower, D. L., and Brown, N.H. (2007) Mutations in the Drosophila aPS2 integrin subunit uncover new features of adhesion site assembly. Dev. Biol. 308, 294-308. PubMed

  • Estrada, B., Maeland, A.D., Gisselbrecht, S.S., Bloor, J.W., Brown, N.H., and Michelson, A.M. (2007) The MARVEL domain protein, Singles Bar, is required for progression past the pre-fusion complex stage of myoblast fusion. Dev. Biol. 307, 328-339. PubMed

  • Dominguez-Gimenz, P., Brown, N.H., and Martin-Bermudo, M.D. (2007) Integrin-ECM interactions regulate the changes in cell shape driving the morphogenesis of the Drosophila wing epithelium. J. Cell Sci., 120, 1061-1071. PubMed

  • Polesello, C., Huelsmann, S., Brown, N.H., and Tapon, N. (2006) The Drosophila RASSF homologue antagonises the Hippo pathway. Curr. Biol. 16, 2459-2465. PubMed

  • Tanentzapf, G., and Brown, N.H. (2006) An interaction between integrin and the talin FERM domain mediates integrin activation but not linkage to the cytoskeleton. Nature Cell Biol. 8, 601-606. PubMed

  • Tanentzapf, G., Martin-Bermudo, M.D., Hicks, M.S. and Brown, N.H. (2006) Multiple factors contribute to integrin-talin interactions in vivo. J. Cell Sci. 119, 1632-1644. PubMed

  • Röper, K., Mao, Y., and Brown, N.H. (2005) Contribution of sequence variation in Drosophila actins to their incorporation into actin-based structures in vivo. J. Cell Sci. 118,  3937-3948. PubMed

  • Bécam, I.E., Tanentzapf, G., Lepesant, J-A., Brown, N.H. and Huynh, J-R. (2005) Integrin-independent repression of  cadherin transcription by talin during axis formation in Drosophila. Nature Cell Biol. 7, 510-516. PubMed

  • Bökel, C., Prokop, A., and Brown, N.H. (2005) Papillote and Piopio, Drosophila ZP-domain proteins required for cell adhesion to the apical extracellular matrix and microtubule organization. J. Cell Sci. 118, 633-642. PubMed

  • Grabbe, C., Zervas, C.G., Hunter, T., Brown, N.H., and Palmer, R.H. (2004) Focal adhesion kinase is not required for integrin function of viability in Drosophila. Development 131,  5795-5805. PubMed

  • Devenport, D and Brown, N.H. (2004) Morphogenesis in the absence of integrins: mutation of both Drosophila b subunits prevents midgut migration. Development 131, 5405-5415. PubMed

  • Narasimha, M. and Brown, N.H. (2004) Novel roles for integrins in epithelial morphogenesis. Curr Biol. 14, 381-385. PubMed

  • Torgler, C.N., Narasimha, M., Knox, A.L., Zervas, C.G., Vernon, M.C. and Brown, N.H. (2004) Tensin stabilises integrin adhesive contacts in Drosophila. Dev. Cell 6, 357-369. PubMed

  • Röper, K., and Brown, N. H. (2004) A spectraplakin is enriched on the fusome and organises microtubules during oocyte specification in Drosophila. Curr. Biol. 14, 99-110. PubMed

  • Röper, K., and Brown, N. H. (2003) Maintaining epithelial integrity: a function for gigantic spectraplakin isoforms in adherens junctions. J. Cell Biol. 162, 1305-1315. PubMed

  • Brown, N. H., Gregory, S. L., Rickoll, W. L., Fessler, L. I., Prout, M., White, R. A. H., and Fristrom, J. W. (2002) Talin is essential for integrin function in Drosophila. Dev. Cell 3, 569-579. PubMed

  • Knox, A. L. and Brown, N. H. (2002) Rap1 GTPase regulation of adherens junctions prevents epithelial cell dispersion. Science 295, 1285-1288. PubMed

  • Boube, M., Martin-Bermudo, M. D., Brown, N. H. and Casanova, J. (2001) Specific tracheal migration is mediated by complementary expression of cell surface proteins. Genes & Dev. 15, 1554-1562. PubMed

  • Zervas, C. G., Gregory, S. L. and Brown, N. H. (2001) Drosophila integrin linked kinase is required at sites of integrin adhesion to link the cytoskeleton to the plasma membrane. J. Cell Biol. 152, 1007-1018. PubMed

  • Martin-Bermudo, M.D. and Brown, N. H. (2000) The localized assembly of extracellular matrix integrin ligands requires cell-cell contact.  J. Cell Sci. 113, 3715-3723. PubMed

  • Kaltschmidt, J.A., Davidson, C.M., Brown, N.H. and Brand, A.H. (2000) Rotation and asymmetry of the mitotic spindle direct asymmetric cell division in the developing central nervous system. Nature Cell Biol., 7-12. PubMed

  • Martin-Bermudo, M. D., Alvarez-Garcia, I. and Brown, N. H. (1999) Migration of the Drosophila primordial midgut cells requires coordination of diverse PS integrin functions. Development 126, 5161-5169. PubMed

  • Martin-Bermudo, M.D. and Brown, N.H. (1999) Uncoupling integrin adhesion and signaling: the bPS cytoplasmic domain is sufficient to regulate gene expression in the Drosophila embryo. Genes & Dev. 13, 729-739. PubMed

  • Gregory, S.L. and Brown, N.H. (1998) kakapo, a gene required for adhesion between and within cell layers in Drosophila, encodes a large cytoskeletal linker protein related to plectin and dystrophin. J. Cell Biol. 143, 1271-1282. PubMed

  • Walsh, E.P. and Brown, N.H. (1998) A screen to identify Drosophila genes required for integrin mediated adhesion. Genetics 150, 791-805. PubMed

  • Martin-Bermudo, M.D., Dunin-Borkowski, O.M. and Brown, N.H. (1998) Modulation of integrin activity is vital for morphogenesis. J. Cell Biol. 141, 1073-1081. PubMed

  • Prokop, A., Martin-Bermudo, M.D., Bate, M. and Brown, N.H. (1998) Absence of PS integrins or laminin A affects extracellular adhesion, but not intracellular assembly, of hemiadherens and neuromuscular junctions in Drosophila embryos. Dev. Biol. 196, 58-76. PubMed

  • Bloor, J.W. and Brown, N.H. (1998) Genetic analysis of the Drosophila aPS2 integrin subunit reveals discrete adhesive, morphogenetic and sarcomeric functions. Genetics 148, 1127-1142. PubMed

  • Martin-Bermudo, M.D., Dunin-Borkowski, O.M. and Brown, N.H. (1997) Specificity of PS integrin function during embryogenesis resides solely in the a subunit extracellular domain. EMBO J. 16, 4184-4193. PubMed

  • Martin-Bermudo, M.D. and Brown, N.H. (1996) Intracellular signals direct integrin localization to sites of function in embryonic muscles. J. Cell Biol. 134, 217-226. PubMed

  • Dunin-Borkowski, O.M., Brown, N.H. and Bate, M. (1995) Anterior-posterior subdivision and the diversification of the mesoderm in Drosophila. Development 121, 4183-4193. PubMed

  • Dunin-Borkowski, O.M. and Brown, N.H. (1995) Mammalian CD2 is an effective heterologous marker of the cell surface in Drosophila. Dev. Biol. 168, 689-693. PubMed

  • Brown, N. H. (1994) Null mutations in the aPS2and bPS integrin subunit genes have distinct phenotypes. Development 120, 1221-1231. PubMed

  • St Johnston, D., Brown, N.H., Gall, J.G., and Jantsch, M. (1992) A conserved double-stranded RNA-binding domain. Proc. Natl. Acad. Sci. U.S.A. 89, 10979-10983. PubMed

  • Jones, G., Brown, N., Manczak, M., Hiremath, S. and Kafatos, F.C. (1990) Molecular cloning, regulation, and complete sequence of a hemocyanin-related, juvenile hormone-suppressible protein from insect hemolymph. J. Biol. Chem. 265, 8596-8602. PubMed

  • Brown, N.H., King, D.L., Wilcox, M. and Kafatos, F.C. (1989) Developmentally regulated alternative splicing of Drosophila integrin PS2 a transcripts.  Cell 59, 185-195. PubMed

  • Grinblat, Y., Brown, N.H. and Kafatos, F.C. (1989) Isolation and characterization of the Drosophila translational elongation factor 2 gene.  Nucl. Acids Res. 17, 7303-7314. PubMed

  • Bray, S.J., Burke, B., Brown, N.H. and Hirsh, J. (1989) Embryonic expression pattern of a family of Drosophila proteins that interact with a central nervous system regulatory element.  Genes & Dev. 3, 1130-1145. PubMed

  • Brown, N.H. and Kafatos, F.C. (1988) Functional cDNA libraries from Drosophila embryos.  J. Mol. Biol. 203, 425-437. PubMed

  • Bogaert, T., Brown, N., and Wilcox, M. (1987) The Drosophila PS2 antigen is an invertebrate integrin that, like the fibronectin receptor, becomes localized to muscle attachments. Cell 51, 929-940. PubMed

  • Wilcox, M., Brown, N., Piovant, M., Smith, R.J. and White, R.A.H. (1984) The Drosophila position-specific antigens are a family of cell surface glycoprotein complexes. EMBO J. 3, 2307-2313. PubMed

  • Komano, T., Brown, N., Inouye, S. and Inouye, M. (1982) Phosphorylation and methylation of proteins during Myxococcus xanthus spore formation. J. Bacteriol. 151, 114-118. PubMed

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Invited reviews, book chapters, etc.

  • Maartens A.P., Brown N.H. (2015) The many faces of cell adhesion during Drosophila muscle development. Dev. Biol. 401(1), 62-74. PubMed

  • Huelsmann S., Brown N.H. (2014) Nuclear positioning by actin cables and perinuclear actin: Special and general? Nucleus 5(3), 219-223. PubMed

  • Bulgakova, N.A., Klapholz, B., Brown, N.H. (2012) Cell adhesion in Drosophila: versatility of cadherin and integrin complexes during development. Curr Opin Cell Biol. 24(5), 702-712. PubMed

  • Brown, N.H. (2011) Extracellular matrix in development: insights from mechanisms conserved between invertebrates and vertebrates. Cold Spring Harb. Perspect. Biol. 3. PubMed

  • Brown, N.H. (2008) Spectraplakins: the cytoskeleton's Swiss army knife. Cell 135, 16-18. PubMed

  • Delon, I. and Brown N. (2008) Cell-matrix adhesion: the Wech connection. Curr Biol. 18, R389-391. PubMed

  • Delon, I. and Brown, N.H. (2007) Integrins and the actin cytoskeleton. Curr. Opin. Cell Biol. 19, 43-50. PubMed

  • Narasimha, M. and Brown, N.H. (2005) Confocal microscopy of Drosophila embryos. In “Cell biology: a laboratory manual, 3rd edition”, de Celis, J., Editor, Academic Press.

  • Narasimha, M. and Brown, N.H. (2006) Integrins and associated proteins in Drosophila development. In “Integrins and development” Danen, E., editor. Landes Bioscience.

  • Torgler, C.N., and Brown, N.H. (2003) Reducing integrins improves the quality of fly life. Sci. Aging Knowledge Environ. 2003, PE28. PubMed

  • Röper, K., Gregory, S. L. and Brown, N. H. (2002) The ‘Spectraplakins’: cytoskeletal giants with characteristics of both spectrin and plakin families. J. Cell Sci. 115, 4215-4225. PubMed

  • Bökel, C. and Brown, N.H. (2002) Integrins in development: moving on, responding to, and sticking to the extracellular matrix. Dev. Cell 3, 311-321. PubMed

  • Zervas, C. G. and Brown, N.H. (2002) Integrin adhesion: when is a kinase a kinase? Curr. Biol. 12, R350-R351. PubMed

  • Brown, N. H. (2000) An integrin chicken and egg problem: which comes first, the extracellular matrix or the cytoskeleton? Curr. Opin. Cell Biol. 12, 629-633. PubMed

  • Brown, N. H. (2000) Cell-cell adhesion via the ECM: integrin genetics in fly and worm. Matrix Biol. 19, 191-201. PubMed

  • Brown, N. H., Gregory, S. L. and Martin-Bermudo, M. D. (2000) Integrins as mediators of morphogenesis in Drosophila. Dev. Biol. 223, 1-16. PubMed

  • Brown, N.H. and Hartley, D.A. (1994) Exploring signalling pathways. Nature 370, 414-415. PubMed

  • Brown, N.H., Bloor, J.W., Dunin-Borkowski, O. and Martin Bermudo, M.D. (1993) Integrins and morphogenesis. Development 119S, 177-183. PubMed

  • Brown, N.H. (1993) Integrins hold Drosophila together.  BioEssays 15, 383-390. PubMed

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