We study the regulation of chromatin structure and function in gene expression and genome organization, using C. elegans as a model system. Our work combines high-throughput sequencing and computational methods with smaller scale genetics and mutant analyses, as well as RNAi screening for functional gene discovery. Our RNAi feeding library is available from Source Bioscience.
We are located in the Wellcome Trust/Cancer Research UK Gurdon Institute at the University of Cambridge.
Much of our research is supported by the Wellcome Trust.